Is it possible that doctors are poisoning the public intentionally? Yes, it is; but they think they are doing the right thing. This article will look at the alarming connections between indigestion, arthritis, money and the scientistic process (scientistic is used as a slur on what parades as science but is in fact directed research, consensus and junk science). This article will not be pleasant reading, but it affects every one of us. The silver lining is that with a subtle understanding, the aphorism An ounce of prevention is worth a pound of cure will truly come to life. You will learn here about one of the greatest hazards of going to your doctor, why he believes he is doing the right thing when in fact he is poisoning you and how, with a simple nutritional approach, you can avoid most of the pitfalls.
In 1897 aspirin came on the market. It is therefore opportune after one hundred years to review what aspirin and its 'children' have wrought.1 By children, I mean the nonsteroidal anti-inflammatory drugs (NSAIDs). These are the most commonly used medication world wide.2,3,4 I have had a bad feeling about NSAIDs for a number of years and have virtually eliminated their use from my practice, but, on reviewing the literature for this article, I came across no less than 207 references on Medline, from the last three years alone, ascribing toxicity and adverse effects of these drugs. It is interesting that aspirin has survived these 100 years. Many of its congeners or children, as I call them, have come and gone. The first important NSAID was phenylbutazone (Butazolidin). After its patent ran out, the brouhaha over its side effects (the provocation of rare cases of failure of the bone marrow with aplastic anemia) eliminated it from the marketplace. Unfortunately, the patented drugs which have followed in its footsteps are also very toxic but it seems that the medical profession has become inured to these. Almost invariably the patient obtains temporary relief from an inflammatory pain with these drugs. So they seem to be useful. The damage to the patient is delayed and not immediately obvious. Though, alas, ever so often it is catastrophic in the end.5 What a sad commentary it is on modern medicine that instead of avoiding these drugs (and in most illnesses there are excellent inexpensive alternative - see below), all we hear from The Establishment is the use of additional drugs to combat the complications. Let us list, however, some of these complications, first of all. As is usually the case, side effects are not side effects at all but are the expected pharmacological or biochemical results of the agents used. They are usually quite predictable and unavoidable if the drugs are taken. Using the term side effects is akin to sloganeering; prejudice is built into the term. The undesirable consequences are given a bad name, thought of as an incidental disadvantage rather than recognizing them as essential features of the pharmacology of the drugs. Here we need to take a short diversion into biochemistry. There exists in our bodies inter alia chemicals with the name prostaglandins. They are derived from essential fatty acids, vis, arachidonic acid via a metabolic pathway which goes by the name of endoperoxide biosynthesis. The initial step is catalyzed by an enzyme called cyclooxygenase. Two forms of cyclooxygenase enzymes exist - COX-1 and COX-2.6,7 COX-1 is important in circumstances where prostaglandins have a protective effect, such as gastric mucus production and the maintenance of renal blood flow. Non steroidal antiinflammatory agents inhibit the synthesis of prostaglandins at one or more points in the endoperoxide pathways. One might note that the pain-relieving mechanism of NSAIDs is, at least in part, in the brain. This may involve inhibition of central nervous system prostaglandins or inhibition of excitatory amino acids or bradykinins.8 The protective prostaglandins play essential roles in every tissue of the body. It is not surprising, then, that poisoning them has widespread effect.9,10 There follow the main headlines of this toxicity: The lining of the stomach and intestines is predictably damaged by NSAIDs, so much so that overt erosions have been detected in 60% of patients receiving long-term NSAID 'therapy'. Bleeding is a common complication.11,12,13,14 It has been estimated that there are 20,000 deaths per annum in America alone from this problem.15 Erosions in the stomach are often symptomatic and patients who are aware of burning in their stomach are sometimes wise enough to stop the poison. The unwary, however, are apt to consult their doctor and, although the medical literature is replete with admonitions about the toxicity of these drugs, it is, alas, extraordinarily common for doctors to pile on additional drugs to combat the side effects.16 The most ironic of these is the introduction of prostaglandin E1 in the form of a drug called misoprostol (Cytotec).17 You see here, we are selectively poisoning the enzyme responsible for making this prostaglandin, and then we add it back in. This phenomenon of using a patented agent to replace a natural product playing an essential role in the body is becoming quite, I shall call it, fashionable in the pharmaceutical industry. It would seem obvious that the best thing is simply not to poison the enzyme system. Additionally, if there is a deficiency in the biochemical mediator or molecule, increasing the nutrient from which it is derived is likely to improve the situation. Arachidonic acid is, of course, an essential unsaturated fatty acid.18 By simply increasing the intake of essential unsaturated fatty acids, it is likely that this problem can be averted. This is also called precursor therapy a term which merely obfuscates the obvious. Another example of the use of a patented agent in a metabolic downstream situation is in the use of serotonin uptake inhibitors such as Prozac. The precursor, tryptophan, is another essential nutrient in our diet, although in this case an amino acid. One cannot but wonder about the role of the authorities in this country. Even though essential fatty acids are an absolute requirement in our diet, there is no Recommended Daily Allowance (RDA). In the case of tryptophan, this supplement has been banned entirely for a number of years, after a scare about toxicity from a particular source, in Japan, and has recently been banned from health food stores altogether. The expensive and short-term amelioration of a problem might be more profitable to the drug industry, unfortunately at the expense of poisoning the public and compounding the cost because of the expense in treating the side effects.19 Before leaving the subject of gastrointestinal damage from NSAIDs, one should include comments about the intestine and colon. Readers of this newsletter will remember the wonderful article by Sherri Rogers describing the leaky gut syndrome.20 It turns out that because of the essential character of NSAIDs, they aggravate this leakage of polypeptides across the lining of the intestines, leading to food intolerances.21,22,23 It has been suggested that the increased incidence of the leaky gut syndrome is due, at least in part, to the widespread use of aspirin and NSAIDs. The colon of many patients has also been damaged with strictures and ulcers24,25,26 from these drugs, and there is a suggestion of a weakening of the immune system27,28 and an increased risk of cancer.29
Liver damage has been reported from NSAIDs somewhat infrequently but catastrophically.30,31 Prostaglandins play an essential role in regulating blood flow through the kidneys. Renal damage has been recognized from these drugs and recounted many times, particularly from Australia.32,33,34,35,36 It seems also that the autoregulation of blood flow through the kidney, which indirectly controls a person's blood pressure, is regularly adversely affected.37,38 The prostaglandins protect the respiratory passages of the lungs and the nose. It is not surprising therefore that rapid acceleration of asthma and a tendency to allergic rhinitis39,40 are well recognized side effects of NSAIDs.41 Do you see the pattern? Some aches and pains are treated with NSAIDs and before long a proportion of the patients require drugs for their stomach, drugs for their hypertension, etc. The business of polypharmacy is immensely destructive. It has been estimated that drug interactions is the rule when a person takes more than three drugs.42 What a shock it is then to read the recommended therapy for side effects from drugs always recommending the use of additional agents.
In very broad terms arthritis can be divided into degenerative and inflammatory. The anti-inflammatory agents do, I must admit, have a legitimate role in select cases of inflammatory arthritis, i.e., in rheumatoid arthritis.43 It is in these illnesses that I occasionally still use these drugs; but the greatest use (I think of it as abuse) of aspirin and NSAIDs is in sprains, the wear-and-tear-arthritis called osteoarthritis.44 This is the stage at which the cumulative damage from sprains progresses to permanent changes, called pathology. Now it is perfectly true that patients taking NSAIDs for an acute inflammation from a sprain, or an exacerbation of their osteoarthritis, obtain temporary relief. Unfortunately herein lies the curse. The body's natural cycle of wear and repair is dependent on the inflammatory process in the repair phase. We are always injuring or bruising ourselves, sometimes so slightly that we are not aware of the pain. The wonderful natural healing mechanism in our bodies takes care of these mini-damages automatically. But when the metabolic pathway for the active agents (prostaglandins) necessary for the repair arm is blocked, it should be evident that we end-up with less repair than we otherwise might have had. Failure of repair of our ligaments, joint capsules and other connective tissue has a long-term damning effect on this organ. Readers of my columns will know that the fascial-ligamentous organ of the whole body can be thought of as a unit.45 It is this precious organ, which maintains form and function, and which is damaged piecemeal when the repair arm of the cycle of wear-and-repair is blocked. We complain not infrequently that our democratically elected politicians never develop a strategy for our welfare. They are always planning to run for the next election. They are always looking for short-term showings rather than long-term results. Unfortunately this rot has spread into Medicine through the politicization of research. Long-term studies are not popular. Not only is the work difficult and takes a long time, but the results are usually much less impressive, nay, they often show harm when short-term 'benefit' can be seen through the temporary alleviation of a presenting symptom with drugs. The fixation on double-blind control cross-over studies does not eliminate the problem and merely lends credibility to these poisons.46 The funding comes in part directly from the pharmaceutical industry, but a lot of it arrives through the back door via the big foundations which in turn are funded by this industry or through our taxes from the National Institute of Health (NIH). It is, paradoxically, in the newfangled pseudo-branch of Medicine Sports Medicine that realization of the uselessness of NSAIDs in acute injuries is beginning to emerge.47
What, you might ask, is a person to do with compelling recurrent back pain, a dysfunctional knee, chronic shoulder pain, etc. The thrust of this article is that Orthopædic medicine is the answer. No, the answer is not a specific drug, not even a specific injection. It is a logical, analytic, diagnostic approach to your problem. Each pain has a cause, and it is the doctor's job to find it. In the musculoskeletal system, perhaps better called the fascioligamentous organ, dysfunction of any ligament, joint capsule or fascia, has distinct manifestations with pain and dysfunction. The pain itself almost always has a distribution which is characteristic of its origin. It is the business of the Orthopædic physician, therefore, to evaluate the patient and identify the source. The tools used in managing these conditions are, or should be, 1) manipulation,48 2) select use of local disinflammation by injection, 3) prolotherapy.49 This is the treatment which refurbishes damaged ligaments through provoking the natural healing process at the site where it is required. How is it then that the public has not heard of Orthopædic medicine? Worse even, most physicians have not heard of it either. The answer is in the mind-set. So strong are the trends, opinions and prejudice in the minds of the medical scientists that they never look at the larger picture.50 Short-term research buttressed by the pseudo-science of the double-blind controlled study, the heaping-up of articles cluttering the databases and journals of the medical establishment, all funded from the same sources, leads inexorably to the pre-planned outcome. The plan, of course, is to promote the use of expensive, and unfortunately harmful, medical care by way of promoting the unnatural interventions with pharmaceuticals and surgery. There are, of course, instances wherein the wonders of modern medicine using these tools achieve great results; indeed, every lie has an element of truth. It remains, however, in this physician's opinion, most unwise to use NSAIDs wholesale. In the last five years, these drugs have become available without a prescription. The profession's first reaction was grief and anger at the retirement of a privilege. Paradoxically, the increased use of these poisons by the public, without supervision, is generating a lot more business for the doctors. The woe, or dialectic, is, therefore, best labeled as an example of crocodile tears.
Until a few years ago, scientific articles were stylized in a pristine form. Analysis dealt merely with objective scientific medical observations. It is interesting to observe how in the last five years the databases of medical knowledge are becoming inundated with such socialistic terms as practice guidelines and consensus conferences.51,52 This is a social engineering technique whereby some bureaucrat, secretary or change agent brings a subject onto the agenda, marshals the favorable evidence, arranges discussion groups (so everyone thinks they have some input), and then summarizes the conference with the pre-determined 'conclusion'. The arrogation of superior knowledge to the trendsetter herding the rest of the population into consensus hails back to the philosopher kings of the Greek philosopher Plato. Its more recent use was promoted by Karl Marx, Lenin and, in America, by The Establishment for which perhaps the closest approximation to identifying the individuals is in the Council on Foreign Relations (CFR).53 We should recognize therefore that trends in medicine are not spontaneous.54 Changes have causes. The marshaling of education in America will be the subject of a forthcoming newsletter and has been documented in summary form as referenced.55,56
If you have been somewhat pessimistic from reading these pages so far, perhaps we should focus on the positive. Let us face it; humanity has lived in want, sloth and ignorance for the majority of its history. It is only since the Renaissance that we have emerged from the Dark Ages, and the beauty of our modern lives is based on the fruits of this wonderful development; the introduction of the freedom to think and experiment. The Catholic Church cast a pall on new thinking from the moment it gained control of the Roman Empire dominating the Dark Ages and controlling Europe for almost two millennia. With the eclipse of dogmatism humanity began an ascent to the fulfillment of its potential. The Renaissance is, however, not merely a scientific awakening, it is best thought of as the age of the middle class. The bourgeois virtues of work, thrift, sobriety, prudence, fidelity, self-reliance, and a concern for one's reputation, are the ethic of this age. It is this ethic which fostered what we now call Western Civilization. There exists a fraternity of the civilized, mostly in Europe and its colonies, present or past. The ethic was distilled by John Ruskin in those famous lectures where Cecil Rhodes sat as a student on the benches.This momentum led to Rhodes' crusade of civilizing the world.57 Alas, his inheritors have perverted his will; or have they been taken over by the powers of evil setting out to control the herd of humanity with false promises and under false pretenses? The cycles through which humanity has gyrated are probably the result of natural forces.58,59 The players, however, can and do affect these cycles to a great measure; and when the forces of evil are on the ascendency it is we, the mass of humanity, who suffer. The reason for dwelling on this historical, philosophical aspect of our problem is to bring you, dear reader, into the camp which should gain ascendency. If we pull together the remnant of our civilization might be able to preserve it. Great bulwarks in this fight are the John Birch Society60, FEE61 and the Cato Institute in Washington, D.C.62 These ideas were portrayed most wonderfully by Henry Grady Weaver.63
In summary, then I propose to you that the funded mind-set of the medical profession has been perverted from the Hippocratic ethic, from the bourgeois principals of voluntary mutually beneficial cooperation between responsible citizens. In the case of doctors, the relationship of the professional to the lay person should have been the epitome of bourgeois ethic. The doctor provides the patient/customer with his best advice based on the holy oath of Hippocrates. Regrettably, we are, however, entering into an age of Platonic medicine: It is governed by central powers who are not motivated to protect your health. They have another agenda. Whether the destructive long-term agenda is satanic, or whether it is merely a desire for control operated through the medium of monopoly capitalism is immaterial. By monopoly capitalism I mean the granting of special rights, through patents or charters, to the select few to exploit the many. As in the secret clubs of Masonry,64,65 there are circles within circles in this corrupt power game, and it is a hallmark of the long-term strategy and cunning planning that the majority of physicians have not realized they have been duped. We are, however, entering into an age of increasing uniformity wherein the doctors are supporting the pharmaceutical and surgical industrial complex cheerfully, blindly, like sheep. In future articles we will look at other examples of monopoly capitalism's influence on the mind set of modern man and that of doctors in particular, we will look at the irrationality of many therpeutic interventions which are 'the norm' in contemporary medicine.
In the case of arthritis there are a number of botanical and other nutritional agents which have a wonderful effect on arthritis. it is not feasible to list them all her, and it is important for a patient to be evaluated by a physician savvy in nutritional medicine because the selection of optimal nutrients is best customized to the person's type and physiology. One cannot forebear, however, from mentioning Niacinamide. It is by far the cheapest and most effective nutrient for osteoarthritis and allied sprains and aches with pains, as well as other forms or arthritis. Very few people react unfavorably to it. In severe cases the ideal dose is 500mg capsules or tablets every four hours. This makes a total daily dose of three grammes. As this is inconvenient to most people, great benefit can accrue to many with smaller doses and less frequent administration. You might wish to start taking two 500mg tablets, twice or three times a day. A long acting, slow release form of Niacinamide is available in 1000mg tablets (from Nature's Life). The benefit is likely be felt after an interval of about six weeks. Not like medication, nutrients take effect slowly. Toxicity is rare, but one might keep in mind that large doses of niacin may reactivate healed peptic ulcers or increase serum uric acid levels. (Niacinamide is somewhat similar to niacin). Large doses of niacin may increase or decrease blood sugar levels in some diabetics. Elevated liver enzymes and, rarely, hepatic toxicity may occur with doses of niacin of over 3,000 mg/day. Sustained-release niacin is significantly more hepatotoxic than is regular niacin. Nausea may be an early warning sign of hepatotoxicity; the dosage should be reduced if nausea occurs. (This is a moderately common side effect, without toxicity, however. Niacinamide may elevate liver enzymes. It does not cause the other side effects listed. Niacin causes a transient skin flush; niacinamide does not. The niacin flush may be blocked by pretreatment with aspirin. Additionally one might consider Pyridoxal 5' Phosphate, Matrixx from Allergy Research Group. Each five capsules contain: Hawthorne extract 735 mg Glucosamine Sulfate 500 mg N-Acetyl Glucosamine 170 mg Chondroitin Sulfate 33 mg L-Proline 270 mg L-Lysine 170 mg Magnesium (citrate) 100 mg Calcium (citrate) 70 mg Zinc (citrate) 10 mg Copper (sebacate) 670 mcg Silicon (Horsetail extract) 17 mg Manganese (citrate) 12 mg Selenium (selenomethionine) 7 mcg Bromelain 600 GDU 25 mg Vitamin C 670 mg Vitamin E (d-Alpha) 133 iu Selenium (selenite) 60 mcg Boron (citrate) 3 mg Molybdenum (sodium molybdate) 417 mcg Contains anti-inflammatory nutrients and herbs which support connective tissue, tendon ligaments, and muscle. This is a customized combination which is the closest preparation to a one size fit all nutritional remedy. The dose is one four times a day. Lyprinol from Life Plus is a unique patented Marine Lipid Extract isolated from the New Zealand Green Lipped Mussel (Perna canaliculus), containing specially concentrated EPA's (Eicosatetraenoic Acids). The dose is one three times a day, increasing to two three times a day after two weeks. We have seen some very effective improvement with this recently introduced product in inflammatory conditions. it works in the prostaglandin cascade, seemingly with benefit and non of the side effects which occur with NSAIDs have been seen.
1Peloso, P. M. Strategies and practice for use of nonsteroidal anti-inflammatory drugs. Scand J Rheumatol Suppl 1996;105:29-43; discussion 44-6
2Bjorkman, D. J. Nonsteroidal anti-inflammatory drug-induced gastrointestinal injury.: Am J Med 1996 Jul 31 101 1A 25S-32S.
3Matzke, G. R. Nonrenal toxicities of acetaminophen, aspirin, and nonsteroidal anti-inflammatory agents. Am J Kidney Dis 1996 Jul 28 1 Suppl 1 S63-70
4Paakkari, H. Epidemiological and financial aspects of the use of non-steroidal anti-inflammatory analgesics. Pharmacol Toxicol 1994;75 Suppl 2:56-9
5Roth, S. H. NSAID gastropathy. A new understanding. Arch Intern Med 1996 Aug 12-26 156 15 1623-8
6Richardson, C. , Emery, P. The clinical implications of inhibition of the inducible form of cyclo-oxygenase. Drug Saf 1996 Oct 15 4 249-60
7Polisson, R. Nonsteroidal anti-inflammatory drugs: practical and theoretical considerations in their selection. Am J Med 1996 Feb 26 100 2A 31S-36S
8Cashman, J., McAnulty, G. Nonsteroidal anti-inflammatory drugs in perisurgical pain management. Mechanisms of action and rationale for optimum use.: Drugs 1995 Jan 49 1 51-70 .
9Agrawal, N. M. Epidemiology and prevention of non-steroidal anti-inflammatory drug effects in the gastrointestinal tract.: Br J Rheumatol 1995 Apr;34 Suppl 1:5-10:
10Agrawal, N. M., Aziz, K. Gastric erosions induced by nonsteroidal anti-inflammatory drugs: clinical significance, pathogenesis, and therapeutic perspectives.: J Assoc Acad Minor Phys 1995 6 3 97-9
11Hawkey, C. J. Review article: aspirin and gastrointestinal bleeding. Aliment Pharmacol Ther 1994 Apr 8 2 141-6
12Lee, M. Prevention and treatment of nonsteroidal anti-inflammatory drug-induced gastropathy. South Med J 1995 May 88 5 507-13
13Bjorkman, D. J., Kimmey, M. B. Nonsteroidal anti-inflammatory drugs and gastrointestinal disease: pathophysiology, treatment and prevention.: Dig Dis 1995 Mar-Apr 13 2 119-29
14Blower, A. L. Considerations for nonsteroidal anti-inflammatory drug therapy: safety.: Scand J Rheumatol Suppl 1996;105:13-24; discussion 25-7:
15Wolfe, M. M. NSAIDs and the gastrointestinal mucosa. Hosp Pract (Off Ed) 1996 Dec 15 31 12 37-44, 47-8.
16Fenn, G. C. Review article: controversies in NSAID-induced gastroduodenal damagedo they matter? Aliment Pharmacol Ther 1994 Feb 8 1 15-26
17Ballinger, A. Cytoprotection with misoprostol: use in the treatment and prevention of ulcers.: Dig Dis 1994 Jan-Feb 12 1 37-45
18Readers are referred to Dr. Dorman's Newsletter No.1 from 1996, Good Fats, Bad Fats.
19De, Pouvourville G. The iatrogenic cost of non-steroidal anti-inflammatory drug therapy. Br J Rheumatol 1995 Apr;34 Suppl 1:19-24
20Readers are referred to Dr. Dorman's Newsletter, Vol 1, No.4 1996.
21Balint, G., Gergely, P Jr Clinical immunotoxicity of antirheumatic drugs.: Inflamm Res 1996 Dec;45 Suppl 2:S91-5.
22Bjarnason, I. Intestinal permeability.: Gut 1994 Jan 35 1 Suppl S18-22
23Bjarnason, I., Macpherson, A. J. Intestinal toxicity of non-steroidal anti-inflammatory drugs.: Pharmacol Ther 1994 Apr-May 62 1-2 145-57
24Kaufman, H. L. , Fischer, A. H. , Carroll, M. , Becker, J. M. Colonic ulceration associated with nonsteroidal anti-inflammatory drugs. Report of three cases Dis Colon Rectum 1996 Jun 39 6 705-10
25Davies, N. M. Toxicity of nonsteroidal anti-inflammatory drugs in the large intestine.: Dis Colon Rectum 1995 Dec 38 12 1311-21
26Robinson, M. H. , Wheatley, T. , Leach, I. H. Nonsteroidal antiinflammatory drug-induced colonic stricture. An unusual cause of large bowel obstruction and perforation. Dig Dis Sci 1995 Feb 40 2 315-9
27Rietveld, J. A. , Pilmore, H. L. , Jones, P. G. , Theis, J. C. , Bowie, D. A. , Dempster, A. G. , Walker, R. J. Necrotising fasciitis: a single centre's experience [see comments] N Z Med J 1995 Mar 8 108 995 72-4 Comment In: N Z Med J 1995 Apr 12;108(997):135.
28Faucheron, J. L. , Parc, R. Non-steroidal anti-inflammatory drug-induced colitis. Int J Colorectal Dis 1996 11 2 99-101
29Lee, F. D. Drug-related pathological lesions of the intestinal tract. Histopathology 1994 Oct 25 4 303-8r
30Manoukian, A. V. , Carson, J. L. Nonsteroidal anti-inflammatory drug-induced hepatic disorders. Incidence and prevention. Drug Saf 1996 Jul 15 1 64-71
31Boelsterli, U. A., Zimmerman, H. J., Kretz-Rommel, A. Idiosyncratic liver toxicity of nonsteroidal antiinflammatory drugs: molecular mechanisms and pathology.: Crit Rev Toxicol 1995 25 3 207-35
32Girgis, L. , Brooks, P. Nonsteroidal anti-inflammatory drugs. Differential use in older patients. Drugs Aging 1994 Feb 4 2 101-12
33Bennett, W. M., Henrich, W. L., Stoff, J. S. The renal effects of nonsteroidal anti-inflammatory drugs: summary and recommendations.: Am J Kidney Dis 1996 Jul 28 1 Suppl 1 S56-62
34Palmer, B. F. , Henrich, W. L. Clinical acute renal failure with nonsteroidal anti-inflammatory drugs. Semin Nephrol 1995 May 15 3 214-27
35Whelton, A. Renal effects of over-the-counter analgesics. J Clin Pharmacol 1995 May 35 5 454-63
36Eknoyan, G. Current status of chronic analgesic and nonsteroidal anti-inflammatory drug nephropathy. Curr Opin Nephrol Hypertens 1994 Mar 3 2 182-8
37Mene, P. , Pugliese, F. , Patrono, C. The effects of nonsteroidal anti-inflammatory drugs on human hypertensive vascular disease. Semin Nephrol 1995 May 15 3 244-52
38de Leeuw PW. Nonsteroidal anti-inflammatory drugs and hypertension. The risks in perspective. Drugs 1996 Feb 51 2 179-87
39Schapowal, A. G. , Simon, H. U. , Schmitz-Schumann, M. Phenomenology, pathogenesis, diagnosis and treatment of aspirin-sensitive rhinosinusitis. Acta Otorhinolaryngol Belg 1995 49 3 235-50
40Senna, G. E. , Passalacqua, G. , Andri, G. , Dama, A. R. , Albano, M. , Fregonese, L. , Andri, L. Nimesulide in the treatment of patients intolerant of aspirin and other NSAIDs. Drug Saf 1996 Feb 14 2 94-103
41Picado, C. Classification of severe asthma exacerbations: a proposal. Eur Respir J 1996 Sep 9 9 1775-8
42Over five thousand articles cover this subject on Medline, in the last three years alone.
43Pincus, T. The underestimated long term medical and economic consequences of rheumatoid arthritis. Drugs 1995;50 Suppl 1:1-14
44Readers might wish to refer to Fact Fiction and Fraud in modern medicine Vol 1 No. 10, Oct 1996.
45Levin SM, The importance of soft tissues for structural support of the body. in Spine: State of the art reviews: Prolotherapy. Henly & Belfus May 1995. p357-364.
46Coulter HL. The controlled clinical trial. Center for Empirical Medicine. Washing DC 1991.
47Leadbetter, W. B. Anti-inflammatory therapy in sports injury. The role of nonsteroidal drugs and corticosteroid injection. Clin Sports Med 1995 Apr 14 2 353-410
48Dabbs, V., Lauretti, W. J. A risk assessment of cervical manipulation vs. NSAIDs for the treatment of neck pain [see comments]: J Manipulative Physiol Ther 1995 Oct 18 8 530-6 Comment in: J Manipulative Physiol Ther 1996 Mar-Apr;19(3):220-1
49Spine: State of the art reviews: Prolotherapy. Ed. Dorman T. Henly & Belfus May 1995.
50van, der Windt DA, van, der Heijden GJ, Scholten, R. J. , Koes, B. W. , Bouter, L. M. The efficacy of non-steroidal anti-inflammatory drugs (NSAIDS) for shoulder complaints. A systematic review. J Clin Epidemiol 1995 May 48 5 691-704
51Soll, A. H. Consensus conference. Medical treatment of peptic ulcer disease. Practice guidelines. Practice Parameters Committee of the American College of Gastroenterology [published erratum appears in JAMA 1996 May 1;275(17):1314] [see comments] JAMA 1996 Feb 28 275 8 622-9 Comment In: Jama 1996 Oct 9;276(14):1135; Discussion 1136-7 ; Comment In: Jama 1996 Oct 9;276(14):1135-6; Discussion 1136-7 ; Comment In: Jama 1996 Oct 9;276(14):1136; Discussion 1136-7.
52Tannenbaum, H. , Davis, P. , Russell, A. S. , Atkinson, M. H. , Maksymowych, W. , Huang, S. H. , Bell, M. , Hawker, G. A. , Juby, A. , Vanner, S. , Sibley, J. An evidence-based approach to prescribing NSAIDs in musculoskeletal disease: a Canadian consensus. Canadian NSAID Consensus Participants [see comments] Can Med Assoc J 1996 Jul 1 155 1 77-88
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55Research Manual: America 2000/Goals 2000 - Moving the nation educationally to a "New World Order", compiled and edited by James R. Patrick, available from Citizens for Academic Excellence; PO Box 1164, Moline, IL 61265. 1994.
56The Road to Socialism and New World Order. Dennis Laurence Cuddy, Ph.D. Pub. Florida Pro-Family Forum, PO Box 1059, Highland City, FL 33846-1059. Telephone: 941-644-6218. 1995.
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60John Birch Society, POB 8040, Appleton, WI 54903. Phone: 414-749-3780.
61FEE, The Freeman, 30South Broadway, Irvington on Hudson, NY 10533. Phone: 914-591-7230.
62Cato Institute; 1000 Massachusetts Ave. NW, Washington, D.C. 20001 Telephone: 800-767-1241.
63Weaver, Henry Grady: The Mainspring of Human Progress. The Foundation for Economic Eduction, Inc. Irvington-on-Hudson, NY 1947.
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